Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer

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Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer. / Andersson, Kristin; Michael, Kristina M.; Luostarinen, Tapio; Waterboer, Tim; Gislefoss, Randi; Hakulinen, Timo; Forslund, Ola; Pawlita, Michael; Dillner, Joakim.

I: American Journal of Epidemiology, Vol. 175, Nr. 7, 2012, s. 685-695.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Andersson, K, Michael, KM, Luostarinen, T, Waterboer, T, Gislefoss, R, Hakulinen, T, Forslund, O, Pawlita, M & Dillner, J 2012, 'Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer', American Journal of Epidemiology, vol. 175, nr. 7, s. 685-695. https://doi.org/10.1093/aje/kwr373

APA

Andersson, K., Michael, K. M., Luostarinen, T., Waterboer, T., Gislefoss, R., Hakulinen, T., ... Dillner, J. (2012). Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer. American Journal of Epidemiology, 175(7), 685-695. https://doi.org/10.1093/aje/kwr373

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MLA

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Author

Andersson, Kristin ; Michael, Kristina M. ; Luostarinen, Tapio ; Waterboer, Tim ; Gislefoss, Randi ; Hakulinen, Timo ; Forslund, Ola ; Pawlita, Michael ; Dillner, Joakim. / Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer. I: American Journal of Epidemiology. 2012 ; Vol. 175, Nr. 7. s. 685-695.

RIS

TY - JOUR

T1 - Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer

AU - Andersson, Kristin

AU - Michael, Kristina M.

AU - Luostarinen, Tapio

AU - Waterboer, Tim

AU - Gislefoss, Randi

AU - Hakulinen, Timo

AU - Forslund, Ola

AU - Pawlita, Michael

AU - Dillner, Joakim

PY - 2012

Y1 - 2012

N2 - Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline seropositivity to HPV types in genus beta species 2 was associated with SCC risk (odds ratio = 1.3, 95% confidence interval: 1.1, 1.7); this was also the case for samples taken more than 18 years before diagnosis (odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). Type-specific persistent seropositivity entailed elevated point estimates for SCC risk for 29 HPV types and decreased point estimates for only 3 types. After multiple hypothesis adjustment, HPV 76 was significantly associated with SCC risk and HPV 9 with BCC risk. In summary, seropositivity for certain HPV types was associated with an increased risk for future development of SCC and BCC.

AB - Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline seropositivity to HPV types in genus beta species 2 was associated with SCC risk (odds ratio = 1.3, 95% confidence interval: 1.1, 1.7); this was also the case for samples taken more than 18 years before diagnosis (odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). Type-specific persistent seropositivity entailed elevated point estimates for SCC risk for 29 HPV types and decreased point estimates for only 3 types. After multiple hypothesis adjustment, HPV 76 was significantly associated with SCC risk and HPV 9 with BCC risk. In summary, seropositivity for certain HPV types was associated with an increased risk for future development of SCC and BCC.

KW - beta papillomavirus

KW - DNA tumor viruses

KW - human papillomavirus

U2 - 10.1093/aje/kwr373

DO - 10.1093/aje/kwr373

M3 - Article

VL - 175

SP - 685

EP - 695

JO - American journal of hygiene

T2 - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 7

ER -