Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones.

Detaljer

Författare
  • Bengt Wesslén
  • Maria Kober
  • Christina Freij-Larsson
  • Åsa Ljungh
  • Marianne Paulsson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Bioteknisk apparatteknik

Nyckelord

Originalspråkengelska
Sidor (från-till)278-284
TidskriftBiomaterials
Volym15
Utgåva nummer4
StatusPublished - 1994
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Freij-Larsson, C., 1996, Center for Chemistry and Chemical Engineering. 52 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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