Protein kinases and phosphatases in B-cell lymphoma

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Abstract

Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. The lymphoma types seen in adults and children vary and the dominant form in children is the B-cell derived Burkitt lymphoma (BL). In contrast to DLBCL, high survival rates in BL are obtained but more research on normal- and tumor B-cells is needed for a better understanding of the cellular mechanisms underlying lymphoma pathogenesis. Phosphorylation and dephosphorylation of enzymes are key events in signal transduction in cells. Protein kinases phosphorylate enzymes while protein phosphatases dephosphorylate them, and these opposite actions must be carefully balanced for normal cell division to occur. The aim of this study was to characterize B-cell lymphomas with emphasis on a panel of kinases and phosphatases previously described as oncogenes (kinases) and tumorsuppressors (phosphatases) in human cancers. We analyzed DLBCL tissue and found the kinases PKC-β II and ZAP70 to be stronger expressed at protein level in a subgroup of the disease associated with poor survival. We further report enhanced activation of DLBCL cells through the B-cell receptor when ZAP70 is introduced. Also, the protein expression of the phosphatases HePTP and PTEN are weaker in BL tissue from children compared to in non-malignant pediatric controls. Our results indicate important roles for the described kinases and phosphatases in B-cell lymphomas.

Detaljer

Författare
  • Marie Fridberg
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicin och hälsovetenskap

Nyckelord

Originalspråkengelska
KvalifikationDoktor
Tilldelande institution
Handledare/Biträdande handledare
Tilldelningsdatum2009 okt 30
Förlag
  • Inst för Laboratoriemedicin, Avd för tumörbiologi, Malmö Universitetssjukhus, Lunds Universitet
Tryckta ISBN978-91-86253-89-9
StatusPublished - 2009
PublikationskategoriForskning

Relaterad forskningsoutput

Fridberg, M., Kjellström, S., Anagnostaki, L., Skogvall, I., Mustelin, T., Thomas Wiebe, Persson, J. L., Michael Dictor & Gjörloff Wingren, A., 2008, I : Pediatric Hematology & Oncology. 25, 6, s. 528-540

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Berglund, M., Thunberg, U., Fridberg, M., Gjörloff Wingren, A., Gullbo, J., Leuchowius, K-J., Amini, R-M., Lagercrantz, S., Biloglav, A., Enblad, G. & Soderberg, O., 2007, I : Leukemia & Lymphoma. 48, 5, s. 1038-1041

Forskningsoutput: TidskriftsbidragLetter

Fridberg, M., Servin, A., Anagnostaki, L., Linderoth, J., Berglund, M., Soderberg, O., Enblad, G., Rosen, A., Mustelin, T., Mats Jerkeman, Persson, J. L. & Gjörloff Wingren, A., 2007, I : Leukemia & Lymphoma. 48, 11, s. 2221-2232

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Visa alla (3)