Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Detaljer

Författare
  • Annette Dalrymple
  • Edward J. Wild
  • Richard Joubert
  • Kirupa Sathasivam
  • Maria Bjorkqvist
  • Åsa Petersén
  • Graham S. Jackson
  • Jeremy D. Isaacs
  • Mark Kristiansen
  • Gillian P. Bates
  • Blair R. Leavitt
  • Geoff Keir
  • Malcolm Ward
  • Sarah J. Tabrizi
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinska grundvetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)2833-2840
TidskriftJournal of Proteome Research
Volym6
Utgivningsnummer7
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa