Pulmonary vascular changes in asthma and COPD.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)144-155
TidskriftPulmonary Pharmacology & Therapeutics
Volym29
Utgivningsnummer2
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa

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