Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Abstract
We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III activity was increased by 6% (p less than 0.05). The mechanism by which pyridoxine acts is unclear but it is hypothesized that pyridoxine-derived PLP may enhance the catabolism of LDL and the activity of AT III by inhibiting their glycosylation.
Detaljer
Författare | |
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Enheter & grupper | |
Externa organisationer |
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Forskningsområden | Ämnesklassifikation (UKÄ) – OBLIGATORISK
Nyckelord |
Originalspråk | engelska |
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Sidor (från-till) | 873-877 |
Antal sidor | 5 |
Tidskrift | Scandinavian Journal of Clinical & Laboratory Investigation |
Volym | 50 |
Utgåva nummer | 8 |
Status | Published - 1990 dec |
Publikationskategori | Forskning |
Peer review utförd | Ja |