Quantification of l-carvone in toothpastes available on the Swedish market

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Quantification of l-carvone in toothpastes available on the Swedish market. / Kroona, Liv; Warfvinge, Gunnar; Isaksson, Marléne; Ahlgren, Camilla; Dahlin, Jakob; Sörensen, Östen; Bruze, Magnus.

I: Contact Dermatitis, Vol. 77, Nr. 4, 01.10.2017, s. 224-230.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Kroona, L, Warfvinge, G, Isaksson, M, Ahlgren, C, Dahlin, J, Sörensen, Ö & Bruze, M 2017, 'Quantification of l-carvone in toothpastes available on the Swedish market', Contact Dermatitis, vol. 77, nr. 4, s. 224-230. https://doi.org/10.1111/cod.12803

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Kroona L, Warfvinge G, Isaksson M, Ahlgren C, Dahlin J, Sörensen Ö et al. Quantification of l-carvone in toothpastes available on the Swedish market. Contact Dermatitis. 2017 okt 1;77(4):224-230. https://doi.org/10.1111/cod.12803

Author

Kroona, Liv ; Warfvinge, Gunnar ; Isaksson, Marléne ; Ahlgren, Camilla ; Dahlin, Jakob ; Sörensen, Östen ; Bruze, Magnus. / Quantification of l-carvone in toothpastes available on the Swedish market. I: Contact Dermatitis. 2017 ; Vol. 77, Nr. 4. s. 224-230.

RIS

TY - JOUR

T1 - Quantification of l-carvone in toothpastes available on the Swedish market

AU - Kroona, Liv

AU - Warfvinge, Gunnar

AU - Isaksson, Marléne

AU - Ahlgren, Camilla

AU - Dahlin, Jakob

AU - Sörensen, Östen

AU - Bruze, Magnus

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. Methods: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results: l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-carvone were found if limonene was listed on the label. Conclusion: The majority of toothpastes on the Swedish market contain l-carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.

AB - Background: Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. Objectives: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market. Methods: l-Carvone in 66 toothpastes was analysed with straight-phase high-performance liquid chromatography. The product labels were studied with regard to limonene. Results: l-Carvone was found in 64 of 66 toothpastes (concentration: 0.00005–0.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of l-carvone were found if limonene was listed on the label. Conclusion: The majority of toothpastes on the Swedish market contain l-carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.

KW - contact allergy

KW - contact dermatitis

KW - flavour

KW - fragrances

KW - high-performance liquid chromatography

KW - l-carvone

KW - limonene

KW - oral lichen planus

KW - oral lichenoid lesions

KW - spearmint

KW - toothpastes

UR - http://www.scopus.com/inward/record.url?scp=85028733948&partnerID=8YFLogxK

U2 - 10.1111/cod.12803

DO - 10.1111/cod.12803

M3 - Article

VL - 77

SP - 224

EP - 230

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 4

ER -