Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation

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Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. / Cereda, Maurizio; Emami, Kiarash; Kadlecek, Stephen; Xin, Yi; Mongkolwisetwara, Puttisarn; Profka, Harrilla; Barulic, Amy; Pickup, Stephen; Månsson, Sven; Wollmer, Per; Ishii, Masaru; Deutschman, Clifford S.; Rizi, Rahim R.

I: Journal of Applied Physiology, Vol. 110, Nr. 2, 2011, s. 499-511.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Cereda, M, Emami, K, Kadlecek, S, Xin, Y, Mongkolwisetwara, P, Profka, H, Barulic, A, Pickup, S, Månsson, S, Wollmer, P, Ishii, M, Deutschman, CS & Rizi, RR 2011, 'Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation', Journal of Applied Physiology, vol. 110, nr. 2, s. 499-511. https://doi.org/10.1152/japplphysiol.00841.2010

APA

Cereda, M., Emami, K., Kadlecek, S., Xin, Y., Mongkolwisetwara, P., Profka, H., ... Rizi, R. R. (2011). Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. Journal of Applied Physiology, 110(2), 499-511. https://doi.org/10.1152/japplphysiol.00841.2010

CBE

Cereda M, Emami K, Kadlecek S, Xin Y, Mongkolwisetwara P, Profka H, Barulic A, Pickup S, Månsson S, Wollmer P, Ishii M, Deutschman CS, Rizi RR. 2011. Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. Journal of Applied Physiology. 110(2):499-511. https://doi.org/10.1152/japplphysiol.00841.2010

MLA

Vancouver

Author

Cereda, Maurizio ; Emami, Kiarash ; Kadlecek, Stephen ; Xin, Yi ; Mongkolwisetwara, Puttisarn ; Profka, Harrilla ; Barulic, Amy ; Pickup, Stephen ; Månsson, Sven ; Wollmer, Per ; Ishii, Masaru ; Deutschman, Clifford S. ; Rizi, Rahim R. / Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. I: Journal of Applied Physiology. 2011 ; Vol. 110, Nr. 2. s. 499-511.

RIS

TY - JOUR

T1 - Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation

AU - Cereda, Maurizio

AU - Emami, Kiarash

AU - Kadlecek, Stephen

AU - Xin, Yi

AU - Mongkolwisetwara, Puttisarn

AU - Profka, Harrilla

AU - Barulic, Amy

AU - Pickup, Stephen

AU - Månsson, Sven

AU - Wollmer, Per

AU - Ishii, Masaru

AU - Deutschman, Clifford S.

AU - Rizi, Rahim R.

PY - 2011

Y1 - 2011

N2 - The aim of this study was to assess the utility of He-3 MRI to noninvasively probe the effects of positive end-expiratory pressure (PEEP) maneuvers on alveolar recruitment and atelectasis buildup in mechanically ventilated animals. Sprague-Dawley rats (n = 13) were anesthetized, intubated, and ventilated in the supine position (He-4-to-O-2 ratio: 4:1; tidal volume: 10 ml/kg, 60 breaths/min, and inspiration-to-expiration ratio: 1:2). Recruitment maneuvers consisted of either a stepwise increase of PEEP to 9 cmH(2)O and back to zero end-expiratory pressure or alternating between these two PEEP levels. Diffusion MRI was performed to image He-3 apparent diffusion coefficient (ADC) maps in the middle coronal slices of lungs (n = 10). ADC was measured immediately before and after two recruitment maneuvers, which were separated from each other with a wait period (8-44 min). We detected a statistically significant decrease in mean ADC after each recruitment maneuver. The relative ADC change was -21.2 +/- 4.1 % after the first maneuver and -9.7 +/- 5.8 % after the second maneuver. A significant relative increase in mean ADC was observed over the wait period between the two recruitment maneuvers. The extent of this ADC buildup was time dependent, as it was significantly related to the duration of the wait period. The two postrecruitment ADC measurements were similar, suggesting that the lungs returned to the same state after the recruitment maneuvers were applied. No significant intrasubject differences in ADC were observed between the corresponding PEEP levels in two rats that underwent three repeat maneuvers. Airway pressure tracings were recorded in separate rats undergoing one PEEP maneuver (n = 3) and showed a significant relative difference in peak inspiratory pressure between pre- and poststates. These observations support the hypothesis of redistribution of alveolar gas due to recruitment of collapsed alveoli in presence of atelectasis, which was also supported by the decrease in peak inspiratory pressure after recruitment maneuvers.

AB - The aim of this study was to assess the utility of He-3 MRI to noninvasively probe the effects of positive end-expiratory pressure (PEEP) maneuvers on alveolar recruitment and atelectasis buildup in mechanically ventilated animals. Sprague-Dawley rats (n = 13) were anesthetized, intubated, and ventilated in the supine position (He-4-to-O-2 ratio: 4:1; tidal volume: 10 ml/kg, 60 breaths/min, and inspiration-to-expiration ratio: 1:2). Recruitment maneuvers consisted of either a stepwise increase of PEEP to 9 cmH(2)O and back to zero end-expiratory pressure or alternating between these two PEEP levels. Diffusion MRI was performed to image He-3 apparent diffusion coefficient (ADC) maps in the middle coronal slices of lungs (n = 10). ADC was measured immediately before and after two recruitment maneuvers, which were separated from each other with a wait period (8-44 min). We detected a statistically significant decrease in mean ADC after each recruitment maneuver. The relative ADC change was -21.2 +/- 4.1 % after the first maneuver and -9.7 +/- 5.8 % after the second maneuver. A significant relative increase in mean ADC was observed over the wait period between the two recruitment maneuvers. The extent of this ADC buildup was time dependent, as it was significantly related to the duration of the wait period. The two postrecruitment ADC measurements were similar, suggesting that the lungs returned to the same state after the recruitment maneuvers were applied. No significant intrasubject differences in ADC were observed between the corresponding PEEP levels in two rats that underwent three repeat maneuvers. Airway pressure tracings were recorded in separate rats undergoing one PEEP maneuver (n = 3) and showed a significant relative difference in peak inspiratory pressure between pre- and poststates. These observations support the hypothesis of redistribution of alveolar gas due to recruitment of collapsed alveoli in presence of atelectasis, which was also supported by the decrease in peak inspiratory pressure after recruitment maneuvers.

KW - atelectasis

KW - ventilator-induced lung injury

KW - respiratory gas

KW - distribution

KW - He-3 diffusion magnetic resonance imaging

KW - apparent

KW - diffusion coefficient

U2 - 10.1152/japplphysiol.00841.2010

DO - 10.1152/japplphysiol.00841.2010

M3 - Article

VL - 110

SP - 499

EP - 511

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 1522-1601

IS - 2

ER -