Randomized, Double-Blind, Dose-Finding Study for Tiotropium when Added to Olodaterol, Administered via the Respimat(®) Inhaler in Patients with Chronic Obstructive Pulmonary Disease.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Combining long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) is beneficial in chronic obstructive pulmonary disease (COPD), as the two classes of bronchodilator have complementary modes of action. The optimal dose for the fixed-dose combination of the LAMA tiotropium and the LABA olodaterol needed to be determined. In this phase II trial, the dose response of tiotropium on top of olodaterol was investigated in a free-dose combination, while other phase II studies have explored different doses of olodaterol on top of tiotropium, with both drugs delivered using the Respimat(®) inhaler.


  • René Aalbers
  • M Reza Maleki-Yazdi
  • Alan Hamilton
  • Stella Waitere-Wijker
  • Yihua Zhao
  • Valeria C Amatto
  • Olaf Schmidt
  • Leif Bjermer
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi
Sidor (från-till)809-822
TidskriftAdvances in Therapy
Utgåva nummer9
StatusPublished - 2015
Peer review utfördJa