Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In type 1 diabetes, pancreatic beta cells are destroyed by chronic autoimmune responses. The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infections have long been considered as candidates for environmental triggers but, given the lack of evidence for an acute, widespread, cytopathic effect in the pancreas in type 1 diabetes or for a closely related temporal association of diabetes onset with such infections, a role for viruses in type 1 diabetes remains unproven. Moreover, viruses have rarely been isolated from the pancreas of individuals with type 1 diabetes, mainly (but not solely) due to the inaccessibility of the organ. Here, we review past and recent literature to evaluate the proposals that chronic, recurrent and, possibly, persistent enteroviral infections occur in pancreatic beta cells in type 1 diabetes. We also explore whether these infections may be sustained by different virus strains over time and whether multiple viral hits can occur during the natural history of type 1 diabetes. We emphasise that only a minority of beta cells appear to be infected at any given time and that enteroviruses may become replication defective, which could explain why they have been isolated from the pancreas only rarely. We argue that enteroviral infection of beta cells largely depends on the host innate and adaptive immune responses, including innate responses mounted by beta cells. Thus, we propose that viruses could play a role in type 1 diabetes on multiple levels, including in the triggering and chronic stimulation of autoimmunity and in the generation of inflammation and the promotion of beta cell dysfunction and stress, each of which might then contribute to autoimmunity, as part of a vicious circle. We conclude that studies into the effects of vaccinations and/or antiviral drugs (some of which are currently on-going) is the only means by which the role of viruses in type 1 diabetes can be finally proven or disproven.

Detaljer

Författare
  • Jessica L. Dunne
  • Sarah J. Richardson
  • Mark A. Atkinson
  • Maria E. Craig
  • Knut Dahl-Jørgensen
  • Malin Flodström-Tullberg
  • Heikki Hyöty
  • Richard A. Insel
  • Åke Lernmark
  • Richard E. Lloyd
  • Noel G. Morgan
  • Alberto Pugliese
Enheter & grupper
Externa organisationer
  • University of New South Wales
  • Oslo university hospital
  • University of Oslo
  • Karolinska University Hospital
  • University of Tampere
  • Pirkanmaa Hospital District
  • Baylor College of Medicine
  • University of Miami
  • Juvenile Diabetes Research Foundation
  • University of Exeter
  • University of Florida
  • Karolinska Institute
  • Insel Consulting, LLC
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
  • Infektionsmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)744-753
TidskriftDiabetologia
Volym62
Utgivningsnummer5
Tidigt onlinedatum2019 jan 23
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa