Redox Chemistry of Hemoglobin-Associated Disorders

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

This Forum addresses oxidative reactions of hemoglobin (Hb) and explores the underlying mechanisms of some of these reactions that contribute to the pathophysiology associated with hemolytic anemia and Hb-based oxygen therapeutics. A special focus of this Forum is on the understanding of naturally occurring mutations in human Hb and how these mutations were influenced overtime by variety of oxidative stresses. What emerges from these contributions is that some hemoglobinopathies involve mutant Hb that resists oxidative challenges, whereas the majority often result in circulatory disorder. The contributors provide in-depth and comprehensive overviews on selected key mechanisms underlying Hb oxidative reactions in health and in disease states and how this knowledge may help in the design of countermeasures against these oxidative and toxicological pathways. Antioxid. Redox Signal. 26, 745-747.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • FDA Center for Biologics Evaluation and Research
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Läkemedelskemi

Nyckelord

Originalspråkengelska
Sidor (från-till)745-747
Antal sidor3
TidskriftAntioxidants and Redox Signaling
Volym26
Utgåva nummer14
StatusPublished - 2017 maj 10
PublikationskategoriForskning
Peer review utfördJa