Relationship between HMF intake and SMF formation in vivo: An animal and human study

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Bibtex

@article{a9eeae5977cd4111bc4f752865257d90,
title = "Relationship between HMF intake and SMF formation in vivo: An animal and human study",
abstract = "Scope: 5-Hydroxymethylfurfural (HMF) is a furanic compound produced in heat-processed foods by nonenzymatic browning reactions. HMF has been demonstrated to be hepato- and nephrotoxic in animals with a link to its metabolite 5-sulfooxymethylfurfural (SMF). To date little is known about either the formation of SMF from ingested HMF or the formation of DNA adducts in animals or human beings. Methods and results: To assess SMF in vivo formation, we first performed a study in mice treated with high/low doses of oral HMF. We found increased concentrations of SMF in plasma and DNA SMF-adducts in leukocytes, hepatic tissue, and kidneys by means of LC-MS/MS, but no spatial formation in such tissues was observed by MALDI-MS imaging technology due to low sensitivity. In a second experiment, we measured the exposure to HMF in a Spanish preadolescent population. We analyzed the concentration of HMF metabolites (plasma, urine) and measured, for the first time, the presence of SMF in plasma and DNA SMF-adducts in leukocytes. Conclusion: This study provides the first evidence that oral HMF is readily transformed into SMF in vivo, giving rise to the formation of DNA adducts in a direct relation with HMF intake, both in animals and human beings.",
keywords = "5-Hydroxymethylfurfural, 5-Sulfooxymethylfurfural, Estimated intake, Heat processing, Maillard reaction",
author = "{Pastoriza de la Cueva}, Silvia and Juana {\'A}lvarez and {\'A}kos V{\'e}gv{\'a}ri and Javier Montilla-G{\'o}mez and Olga Cruz-L{\'o}pez and Cristina Delgado-Andrade and Rufi{\'a}n-Henares, {Jos{\'e} A.}",
year = "2017",
month = "3",
doi = "10.1002/mnfr.201600773",
language = "English",
volume = "61",
journal = "Molecular Nutrition and Food Research",
issn = "1613-4133",
publisher = "John Wiley & Sons",
number = "3",

}