Relationship Between Mild Primary Hyperparathyroidism and Left Ventricular Structure and Diastolic Performance

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Aim: This study aims to investigate cardiac structure and function in patients with asymptomatic primary hyperparathyroidism (pHPT) and if there is any relation to severity regarding serum levels of calcium (Ca) and parathyroid hormone. Methods and Results: We consecutively included 50 patients (mean age 62.9 +/- 11 years, 45 women) with clinically diagnosed pHPT. We prospectively recruited 50 healthy control subjects, matched for age and sex. Standard transthoracic echocardiographic examination was performed using the 4 standard views and structural parameters as well as left ventricular (LV) systolic and diastolic function was determined. Mean LV ejection fraction and atrioventricular plane displacement were on average normal and did not differ between patients and controls. However, pHPT patients had significantly greater LV mass (148 +/- 37 vs. 127 +/- 29 g, P = 0.002), LV end diastolic area (81 +/- 20 vs. 68 +/- 18 cm(2), p = 0.003), LV posterior wall diameter (8.9 +/- 1 vs. 8.1 +/- 1 min, P = 0.006), and LA size (21 +/- 3 vs. 19 +/- 2 mm, P < 0.001). A moderate to severe LV diastolic filling impairment was present in substantially more pHPT patients, compared with control subjects (36% vs. 4%, P < 0:001). Conclusion: Patients with asymptomatic pHPT showed LV structural changes and impaired LV diastolic function.

Detaljer

Författare
  • Mats Birgander
  • Anne-Greth Bondeson
  • Lennart Bondeson
  • Ronnie Willenheimer
  • Erik Rydberg
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
  • Klinisk medicin
  • Cancer och onkologi
  • Kardiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)187-191
TidskriftThe Endocrinologist
Volym19
Utgåva nummer4
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Mats Birgander, 2011, Cardiology, Dept of Clinical Sciences, Faculty of Medicine. 116 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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