Relationship between selected DNA polymorphisms and coronary artery disease complications

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Relationship between selected DNA polymorphisms and coronary artery disease complications. / Wirtwein, Marcin; Melander, Olle; Sjögren, Marketa; Hoffmann, Michal; Narkiewicz, Krzysztof; Gruchala, Marcin; Sobiczewski, Wojciech.

I: International Journal of Cardiology, Vol. 228, 01.02.2017, s. 814-820.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Wirtwein, Marcin ; Melander, Olle ; Sjögren, Marketa ; Hoffmann, Michal ; Narkiewicz, Krzysztof ; Gruchala, Marcin ; Sobiczewski, Wojciech. / Relationship between selected DNA polymorphisms and coronary artery disease complications. I: International Journal of Cardiology. 2017 ; Vol. 228. s. 814-820.

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TY - JOUR

T1 - Relationship between selected DNA polymorphisms and coronary artery disease complications

AU - Wirtwein, Marcin

AU - Melander, Olle

AU - Sjögren, Marketa

AU - Hoffmann, Michal

AU - Narkiewicz, Krzysztof

AU - Gruchala, Marcin

AU - Sobiczewski, Wojciech

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6 years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19). Results During follow-up period, 245 participants died; 114 due to CV causes. A fatal or non-fatal CV event occurred in 882 participants including 214 ACS, 578 revascularizations and 90 strokes. The alleles of the following SNPs: rs1746048 (CXCL12), rs9818870 (MRAS) and rs17114036 (PPAP2B) were associated with a higher risk of MACE and the alleles of SNPs rs1746048 (CXCL12) and rs1122608 (LDLR) were associated with a higher risk of revascularization. The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. Despite the lack of relationship between significant CAD and GRS19, in the top quartile of GRS19 there was significant relationship between GRS19 and combined endpoint, MACE, ACS, and revascularization. Conclusions Conclusions. The SNPs of CXCL12 and LDLR were associated with risk of revascularization and CXCL12, LPA, MRAS, and PPAP2B were associated with the risk of MACE. GRS19 determines CV complications in CAD patients with the highest genetic risk score values.

AB - Background Coronary heart disease (CHD) development is complex in origin, with contributions from well-defined lifestyle and not well-determined genetic risk factors. The aim of this study is to report the relationship between certain SNPs and the risk of cardiovascular (CV) complications in patients with CAD confirmed by coronary angiography. Methods In the present study, 1345 subjects with CHD were included. The median follow-up period was 8.6 years. 19 SNPs were investigated for any association with Major Advanced CV Events (MACE), Acute Coronary Syndromes (ACS) and Revascularizations. We modeled the 19 SNPs as a multilocus genetic risk score (GRS19). Results During follow-up period, 245 participants died; 114 due to CV causes. A fatal or non-fatal CV event occurred in 882 participants including 214 ACS, 578 revascularizations and 90 strokes. The alleles of the following SNPs: rs1746048 (CXCL12), rs9818870 (MRAS) and rs17114036 (PPAP2B) were associated with a higher risk of MACE and the alleles of SNPs rs1746048 (CXCL12) and rs1122608 (LDLR) were associated with a higher risk of revascularization. The alleles of rs12190287 (MRAS), rs121902287 (TCF21) and rs2259816 (HNF1a) were associated with a higher risk of ACS. Despite the lack of relationship between significant CAD and GRS19, in the top quartile of GRS19 there was significant relationship between GRS19 and combined endpoint, MACE, ACS, and revascularization. Conclusions Conclusions. The SNPs of CXCL12 and LDLR were associated with risk of revascularization and CXCL12, LPA, MRAS, and PPAP2B were associated with the risk of MACE. GRS19 determines CV complications in CAD patients with the highest genetic risk score values.

KW - Coronary artery disease

KW - DNA polymorphisms

KW - Hypertension

UR - http://www.scopus.com/inward/record.url?scp=84997496903&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2016.11.060

DO - 10.1016/j.ijcard.2016.11.060

M3 - Article

VL - 228

SP - 814

EP - 820

JO - European Journal of Cardiology

JF - European Journal of Cardiology

SN - 0167-5273

ER -