Relationship of Nocturnal Sleep Dysfunction and Pain Subtypes in Parkinson's Disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Background: Little research has been conducted regarding the relationship between sleep disorders and different pain types in Parkinson's disease (PD). Objective: To explore the influence of the various pain subtypes experienced by PD patients on sleep. Methods: Three hundred consecutive PD patients were assessed with the PD Sleep Scale-Version 2 (PDSS-2), King's PD Pain Scale (KPPS), King's PD Pain Questionnaire (KPPQ), Visual Analog Scales for Pain (VAS-Pain), and Hospital Anxiety and Depression Scale. Results: According to the PDSS-2, 99.3% of our sample suffered from at least one sleep issue. Those who reported experiencing any modality of pain suffered significantly more from sleep disorders than those who did not (all, P < 0.003). The PDSS-2 showed moderate-to-high correlations with the KPPS (rS = 0.57), KPPQ (0.57), and VAS-Pain (0.35). When PDSS-2 items 10 to 12 (pain-related) were excluded, the correlation values decreased to 0.50, 0.51, and 0.28, respectively, while these items showed moderate-to-high correlations with KPPS (0.56), KPPQ (0.54), and VAS-Pain (0.42). Among the variables analyzed, multiple linear regression models suggested that KPPS and KPPQ were the most relevant predictors of sleep disorders (as per the PDSS-2), although following exclusion of PDSS-2 pain items, depression was the relevant predictor. Depression and anxiety were the most relevant predictors in the analysis involving the VAS-Pain. Regression analysis, considering only the KPPS domains, showed that nocturnal and musculoskeletal pains were the best predictors of overall nocturnal sleep disorder. Conclusions: Pain showed a moderate association with nocturnal sleep dysfunction in PD. Some pain subtypes had a greater effect on sleep than others.

Detaljer

Författare
  • EUROPAR & MDS Non-Motor PD Study Group
  • Pablo Martinez-Martin
  • Alexandra M. Rizos
  • John B. Wetmore
  • Angelo Antonini
  • Per Odin
  • Suvankar Pal
  • Rani Sophia
  • Camille Carroll
  • Davide Martino
  • Cristian Falup-Pecurariu
  • Belinda Kessel
  • Thomasin Andrews
  • Dominic Paviour
  • Claudia Trenkwalder
  • Kallol Ray Chaudhuri
Enheter & grupper
Externa organisationer
  • CIBER Enfermedades Neurodegenerativas (CIBERNED)
  • King's College Hospital
  • University of Padova
  • Derriford Hospital
  • University of Calgary
  • Transylvania University Brasov
  • Guy's and St Thomas' NHS Foundation Trust
  • St George's Hospital, London
  • Carlos III Health Institute
  • King's College London
  • Forth Valley Royal Hospital
  • Yeovil District Hospital
  • Paracelsus-Elena-Klinik Kassel
  • University Medical Center Göttingen
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)57-64
TidskriftMovement Disorders Clinical Practice
Volym6
Utgivningsnummer1
Tidigt onlinedatum2018 okt 13
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa