Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background/Objective: Intracerebral hemorrhage (ICH) patients commonly have concomitant white matter lesions (WML) which may be associated with poor outcome. We studied if WML affects hematoma expansion (HE) and post-stroke functional outcome in a post hoc analysis of patients from randomized controlled trials. Methods: In ICH patients from the clinical trials MISTIE II and CLEAR III, WML grade on diagnostic computed tomography (dCT) scan (dCT, < 24 h after ictus) was assessed using the van Swieten scale (vSS, range 0–4). The primary outcome for HE was > 33% or > 6 mL ICH volume increase from dCT to the last pre-randomization CT (< 72 h of dCT). Secondary HE outcomes were: absolute ICH expansion, > 10.4 mL total clot volume increase, and a subgroup analysis including patients with dCT < 6 h after ictus using the primary HE definition of > 33% or > 6 mL ICH volume increase. Poor functional outcome was assessed at 180 days and defined as modified Rankin Scale (mRS) ≥ 4, with ordinal mRS as a secondary endpoint. Results: Of 635 patients, 55% had WML grade 1–4 at dCT (median 2.2 h from ictus) and 13% had subsequent HE. WML at dCT did not increase the odds for primary or secondary HE endpoints (P ≥ 0.05) after adjustment for ICH volume, intraventricular hemorrhage volume, warfarin/INR > 1.5, ictus to dCT time in hours, age, diabetes mellitus, and thalamic ICH location. WML increased the odds for having poor functional outcome (mRS ≥ 4) in univariate analyses (vSS 4; OR 4.16; 95% CI 2.54–6.83; P < 0.001) which persisted in multivariable analyses after adjustment for HE and other outcome risk factors. Conclusions: Concomitant WML does not increase the odds for HE in patients with ICH but increases the odds for poor functional outcome. Clinical Trial Registration: trial-identifers: NCT00224770 and NCT00784134.


  • Björn M. Hansen
  • Natalie Ullman
  • John Muschelli
  • Bo Norrving
  • Rachel Dlugash
  • Radhika Avadhani
  • Issam Awad
  • Mario Zuccarello
  • Wendy C. Ziai
  • Daniel F. Hanley
  • Richard E. Thompson
  • Arne Lindgren
  • MISTIE and CLEAR Investigators
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • The Children's Hospital of Philadelphia
  • Johns Hopkins Bloomberg School of Public Health
  • Johns Hopkins University
  • University of Chicago
  • University of Cincinnati

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi


Sidor (från-till)516-524
Antal sidor9
TidskriftNeurocritical Care
Utgåva nummer2
Tidigt onlinedatum2020 feb 5
StatusPublished - 2020 okt
Peer review utfördJa