Reovirus type 1 associated with meningitis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy. RNA-gel electrophoresis, immunofluorescence and virus neutralization identified the pathogen isolated from CSF as reovirus type 1. Antibody determination by immunofluorescence of paired sera showed a significant antibody titre rise to the CSF isolate and neutralization test revealed a greater than 4-fold antibody titre rise to the CSF isolate. The CSF isolate was also neutralized by reovirus type 1 antibodies. This report represents one of a few associating reovirus with CNS symptoms in humans.

Detaljer

Författare
  • Hugo Johansson
  • Tomas Sveger
  • Karin Ahlfors
  • Jarl Ekstrand
  • Lennart Svensson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Originalspråkengelska
Sidor (från-till)117-120
TidskriftScandinavian Journal of Infectious Diseases
Volym28
Utgåva nummer2
StatusPublished - 1996
PublikationskategoriForskning
Peer review utfördJa