Repeated Structural Imaging Reveals Nonlinear Progression of Experience-Dependent Volume Changes in Human Motor Cortex

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Abstract

Evidence for experience-dependent structural brain change in adult humans is accumulating. However, its time course is not well understood, as intervention studies typically consist of only 2 imaging sessions (before vs. after training).We acquired up to 18 structural magnetic resonance images over a 7-week period while 15 right-handed participants practiced left-hand writing and drawing. After 4 weeks, we observed increases in gray matter of both left and right primary motor cortices relative to a control group; 3 weeks later, these differences were no longer reliable. Time-series analyses revealed that gray matter in the primary motor cortices expanded during the first 4weeks and then partially renormalized, in particular in the right hemisphere, despite continued practice and increasing task proficiency. Similar patterns of expansion followed by partial renormalization are also found in synaptogenesis, cortical map plasticity, and maturation, and may qualify as a general principle of structural plasticity. Research on human brain plasticity needs to encompass more than 2 measurement occasions to capture expansion and potential renormalization processes over time.

Detaljer

Författare
  • Elisabeth Wenger
  • Simone Kühn
  • Julius Verrel
  • Johan Mårtensson
  • Nils Christian Bodammer
  • Ulman Lindenberger
  • Martin Lövdén
Enheter & grupper
Externa organisationer
  • University Medical Center Hamburg-Eppendorf
  • Stockholms universitet
  • Max Planck Institute for Human Development
  • Karolinska Institute
  • European University Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)2911-2925
Antal sidor15
TidskriftCerebral Cortex
Volym27
Utgivningsnummer5
StatusPublished - 2017 maj 1
PublikationskategoriForskning
Peer review utfördJa