Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring.

Detaljer

Författare
  • Mohamed Amgad
  • Lee A. D. Cooper
  • International Immuno-Oncology Biomarker Working Group
  • Anna Ehinger (Medarbetare)
Enheter & grupper
Externa organisationer
  • Emory University
  • Northwestern University Feinberg School of Medicine
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Artikelnummer16
Tidskriftnpj Breast Cancer
Volym6
Utgåva nummer16
StatusPublished - 2020 maj 12
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Ehinger, A. & 1 andra, Salgado, R., 2020 maj 12, I : npj Breast Cancer. 6, 17.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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