Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Oligodendrocytes are part of the glial cells located in the central nervous system, capable of providing trophic support to neurons and ensheathing their axons. These cells can become dysfunctional under pathologic condition. Rodent and human pluripotent stem cells are inexhaustible sources for producing oligodendrocytes that can be used for disease modeling and cell replacement therapy studies. They also offer many opportunities to model the contribution of oligodendrocytes in non-genetic disorders such as multiple system atrophy. In this method article, we provide robust and reproducible differentiation protocols to obtain oligodendrocyte progenitor cells and purify them using fluorescence activated cell sorting.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)58-66
Antal sidor9
TidskriftStem Cell Research
Volym20
StatusPublished - 2017 apr 1
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Carla Azevedo, 2020, Lund: Lund University, Faculty of Medicine. 119 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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