Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

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Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition. / Costas, Laura; Lujan-Barroso, Leila; Benavente, Yolanda; Allen, Naomi E.; Amiano, Pilar; Ardanaz, Eva; Besson, Caroline; Boeing, Heiner; Bueno-de-Mesquita, Bas; Cervenka, Iris; Fortner, Renée T.; Fournier, Agnès; Gunter, Marc; Harlid, Sophia; Huerta, José María; Jerkeman, Mats; Jirström, Karin; Kaaks, Rudolf; Karakatsani, Anna; Khaw, Kay Tee; Kotanidou, Anastasia; Lund, Eiliv; Masala, Giovanna; Mattiello, Amalia; Melin, Beatrice; Menéndez, Virginia; Murphy, Neil; Nieters, Alexandra; Overvad, Kim; Riboli, Elio; Sacerdote, Carlotta; Sánchez, Maria Jose; Schmidt, Julie A.; Sieri, Sabina; Tjønneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; Vermeulen, Roel; Weiderpass, Elisabete; de Sanjosé, Silvia; Agudo, Antonio; Casabonne, Delphine.

I: American Journal of Epidemiology, Vol. 188, Nr. 2, 2019, s. 274-281.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Costas, L, Lujan-Barroso, L, Benavente, Y, Allen, NE, Amiano, P, Ardanaz, E, Besson, C, Boeing, H, Bueno-de-Mesquita, B, Cervenka, I, Fortner, RT, Fournier, A, Gunter, M, Harlid, S, Huerta, JM, Jerkeman, M, Jirström, K, Kaaks, R, Karakatsani, A, Khaw, KT, Kotanidou, A, Lund, E, Masala, G, Mattiello, A, Melin, B, Menéndez, V, Murphy, N, Nieters, A, Overvad, K, Riboli, E, Sacerdote, C, Sánchez, MJ, Schmidt, JA, Sieri, S, Tjønneland, A, Trichopoulou, A, Tumino, R, Vermeulen, R, Weiderpass, E, de Sanjosé, S, Agudo, A & Casabonne, D 2019, 'Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition', American Journal of Epidemiology, vol. 188, nr. 2, s. 274-281. https://doi.org/10.1093/aje/kwy259

APA

CBE

Costas L, Lujan-Barroso L, Benavente Y, Allen NE, Amiano P, Ardanaz E, Besson C, Boeing H, Bueno-de-Mesquita B, Cervenka I, Fortner RT, Fournier A, Gunter M, Harlid S, Huerta JM, Jerkeman M, Jirström K, Kaaks R, Karakatsani A, Khaw KT, Kotanidou A, Lund E, Masala G, Mattiello A, Melin B, Menéndez V, Murphy N, Nieters A, Overvad K, Riboli E, Sacerdote C, Sánchez MJ, Schmidt JA, Sieri S, Tjønneland A, Trichopoulou A, Tumino R, Vermeulen R, Weiderpass E, de Sanjosé S, Agudo A, Casabonne D. 2019. Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition. American Journal of Epidemiology. 188(2):274-281. https://doi.org/10.1093/aje/kwy259

MLA

Vancouver

Author

Costas, Laura ; Lujan-Barroso, Leila ; Benavente, Yolanda ; Allen, Naomi E. ; Amiano, Pilar ; Ardanaz, Eva ; Besson, Caroline ; Boeing, Heiner ; Bueno-de-Mesquita, Bas ; Cervenka, Iris ; Fortner, Renée T. ; Fournier, Agnès ; Gunter, Marc ; Harlid, Sophia ; Huerta, José María ; Jerkeman, Mats ; Jirström, Karin ; Kaaks, Rudolf ; Karakatsani, Anna ; Khaw, Kay Tee ; Kotanidou, Anastasia ; Lund, Eiliv ; Masala, Giovanna ; Mattiello, Amalia ; Melin, Beatrice ; Menéndez, Virginia ; Murphy, Neil ; Nieters, Alexandra ; Overvad, Kim ; Riboli, Elio ; Sacerdote, Carlotta ; Sánchez, Maria Jose ; Schmidt, Julie A. ; Sieri, Sabina ; Tjønneland, Anne ; Trichopoulou, Antonia ; Tumino, Rosario ; Vermeulen, Roel ; Weiderpass, Elisabete ; de Sanjosé, Silvia ; Agudo, Antonio ; Casabonne, Delphine. / Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition. I: American Journal of Epidemiology. 2019 ; Vol. 188, Nr. 2. s. 274-281.

RIS

TY - JOUR

T1 - Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

AU - Costas, Laura

AU - Lujan-Barroso, Leila

AU - Benavente, Yolanda

AU - Allen, Naomi E.

AU - Amiano, Pilar

AU - Ardanaz, Eva

AU - Besson, Caroline

AU - Boeing, Heiner

AU - Bueno-de-Mesquita, Bas

AU - Cervenka, Iris

AU - Fortner, Renée T.

AU - Fournier, Agnès

AU - Gunter, Marc

AU - Harlid, Sophia

AU - Huerta, José María

AU - Jerkeman, Mats

AU - Jirström, Karin

AU - Kaaks, Rudolf

AU - Karakatsani, Anna

AU - Khaw, Kay Tee

AU - Kotanidou, Anastasia

AU - Lund, Eiliv

AU - Masala, Giovanna

AU - Mattiello, Amalia

AU - Melin, Beatrice

AU - Menéndez, Virginia

AU - Murphy, Neil

AU - Nieters, Alexandra

AU - Overvad, Kim

AU - Riboli, Elio

AU - Sacerdote, Carlotta

AU - Sánchez, Maria Jose

AU - Schmidt, Julie A.

AU - Sieri, Sabina

AU - Tjønneland, Anne

AU - Trichopoulou, Antonia

AU - Tumino, Rosario

AU - Vermeulen, Roel

AU - Weiderpass, Elisabete

AU - de Sanjosé, Silvia

AU - Agudo, Antonio

AU - Casabonne, Delphine

PY - 2019

Y1 - 2019

N2 - The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

AB - The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.

U2 - 10.1093/aje/kwy259

DO - 10.1093/aje/kwy259

M3 - Article

VL - 188

SP - 274

EP - 281

JO - American journal of hygiene

T2 - American journal of hygiene

JF - American journal of hygiene

SN - 0002-9262

IS - 2

ER -