Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

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Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season. / Samuelsson, U.; Lindblad, B.; Carlsson, Annelie; Forsander, G.; Ivarsson, Sten; Kockum, I.; Lernmark, Åke; Marcus, C.; Ludvigsson, J.

I: Diabetes/Metabolism Research & Reviews, Vol. 29, Nr. 1, 2013, s. 85-89.

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T1 - Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season

AU - Samuelsson, U.

AU - Lindblad, B.

AU - Carlsson, Annelie

AU - Forsander, G.

AU - Ivarsson, Sten

AU - Kockum, I.

AU - Lernmark, Åke

AU - Marcus, C.

AU - Ludvigsson, J.

PY - 2013

Y1 - 2013

N2 - Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p < 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p < 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p < 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p < 0.000 and p < 0.01, respectively). Girls had higher C-peptide than boys (p < 0.05), especially in early puberty. Conclusions Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials. Copyright (C) 2012 John Wiley & Sons, Ltd.

AB - Background There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease. We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D. Methods In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D. Results C-peptide was lower in younger children, 010 years of age (0.23 +/- 0.20 nmol/L) than in older children, 1118 years of age (0.34 +/- 0.28 nmol/L) (p < 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p < 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p < 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p < 0.000 and p < 0.01, respectively). Girls had higher C-peptide than boys (p < 0.05), especially in early puberty. Conclusions Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials. Copyright (C) 2012 John Wiley & Sons, Ltd.

KW - C-peptide

KW - children

KW - type 1 diabetes

KW - seasonal variation

KW - gender

KW - immune

KW - intervention

U2 - 10.1002/dmrr.2365

DO - 10.1002/dmrr.2365

M3 - Article

C2 - 23081842

VL - 29

SP - 85

EP - 89

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

IS - 1

ER -