Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. The gene product of G72 is an activator of DAAO (D-amino acid oxidase), which is the only enzyme oxidising D-serine. D-serine is an important co-agonist for the NMDA glutamate receptor and plays a role in neuronal migration and cell death. Studies of D-serine revealed lower serum levels in schizophrenia patients as compared to healthy controls. Furthermore, administration of D-serine as add-on medication reduced the symptoms of schizophrenia. The underlying mechanism of the involvement of G72 and DAAO in schizophrenia is probably based on decreased levels of D-serine and decreased NMDA receptor functioning in patients. The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia.

Detaljer

Författare
  • M. P.M. Boks
  • T. Rietkerk
  • M. H. van de Beek
  • I. E. Sommer
  • T. J. de Koning
  • R. S. Kahn
Externa organisationer
  • University Medical Center Utrecht
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Annan klinisk medicin

Nyckelord

Originalspråkengelska
Sidor (från-till)567-572
Antal sidor6
TidskriftEuropean Neuropsychopharmacology
Volym17
Utgåva nummer9
StatusPublished - 2007 sep 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa