RIFM fragrance ingredient safety assessment, 2-ethyl-5-methoxybicyclo[2.2.1]heptane, CAS registry number 122795-41-9

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) (CAS # 211299-54-6) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) show that it is not genotoxic, and that there are no safety concerns for skin sensitization under the current, declared levels of use. Data from 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) provide a calculated MOE >100 for the repeated dose toxicity endpoint. The reproductive and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class III material, and the exposure to 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) is below the TTC (0.0015 mg/kg/day and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) is not expected to be phototoxic/photoallergenic. For the environmental endpoints, 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R) is not PBT as per the IFRA Environmental Standards, and its risk quotients (i.e., PEC/PNEC) for the aquatic environment based on its current volume of use in Europe and North America are <1.

Detaljer

Författare
  • A. M. Api
  • D. Belsito
  • D. Botelho
  • G. A. Burton
  • J. Buschmann
  • M. L. Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • M. Francis
  • A. D. Fryer
  • L. Jones
  • K. Joshi
  • S. La Cava
  • A. Lapczynski
  • D. C. Liebler
  • D. O'Brien
  • A. Patel
  • T. M. Penning
  • G. Ritacco
  • J. Romine
  • N. Sadekar
  • D. Salvito
  • T. W. Schultz
  • I. G. Sipes
  • G. Sullivan
  • Y. Thakkar
  • Y. Tokura
  • S. Tsang
Externa organisationer
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Hamamatsu University School of Medicine
  • Vanderbilt University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmakologi och toxikologi
Originalspråkengelska
TidskriftFood and Chemical Toxicology
StatusPublished - 2019 feb 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa