RIFM fragrance ingredient safety assessment, Benzyl propionate, CAS Registry Number 122-63-4.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Detaljer

Författare
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • V T Politano
  • G Ritacco
  • D Salvito
  • T W Schultz
  • J Shen
  • I G Sipes
  • B Wall
  • D K Wilcox
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
Originalspråkengelska
TidskriftFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Tidigt onlinedatum2015 dec 17
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa