RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3

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Summary: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).


  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dekant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • J. F. Lalko
  • A. Lapczynski
  • D. C. Liebler
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
Externa organisationer
  • Columbia University
  • Skåne University Hospital
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Tennessee
  • University of Arizona
  • Research Institute for Fragrance Materials, Inc.
  • University of Minnesota system

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi
  • Farmakologi och toxikologi


Sidor (från-till)S192-S200
TidskriftFood and Chemical Toxicology
StatusPublished - 2016 nov 1
Peer review utfördJa
Externt publiceradJa