RIFM fragrance ingredient safety assessment, α-Ionone, CAS Registry Number 127-41-3.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Detaljer

Författare
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • T W Schultz
  • J Shen
  • I G Sipes
  • B Wall
  • D K Wilcox
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
Originalspråkengelska
Sidor (från-till)S1-S10
TidskriftFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volym97S
StatusPublished - 2016
PublikationskategoriForskning
Peer review utfördJa