RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Summary: The existing information supports the use of this material as described in this safety assessment. Isobutyl propionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog isobutyl acetate (CAS # 110-19-0) show that isobutyl propionate is not expected to be genotoxic. Data from read-across analog isoamyl acetate (CAS # 123-92-2) show that there are no safety concerns for isobutyl propionate for skin sensitization under the current declared levels of use. The repeated dose and reproductive endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to isobutyl propionate is below the TTC (0.03 mg/kg/day and 0.03 mg/kg/day, respectively). For the local respiratory endpoint, a calculated MOE >100 was provided by read-across analog butyl acetate (CAS # 123-86-4). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl propionate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; isobutyl propionate is not PBT as per the IFRA Environmental Standards. For the risk assessment, isobutyl propionate was not able to be risk screened as there were no reported volumes of use for North America or Europe in the 2015 IFRA Survey.

Detaljer

Författare
  • A. M. Api
  • D. Belsito
  • D. Botelho
  • G. A. Burton
  • J. Buschmann
  • M. L. Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • M. Francis
  • A. D. Fryer
  • L. Jones
  • K. Joshi
  • S. La Cava
  • A. Lapczynski
  • D. C. Liebler
  • D. O'Brien
  • A. Patel
  • T. M. Penning
  • G. Ritacco
  • J. Romine
  • N. Sadekar
  • D. Salvito
  • T. W. Schultz
  • I. G. Sipes
  • G. Sullivan
  • Y. Thakkar
  • Y. Tokura
  • S. Tsang
Externa organisationer
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University School of Medicine
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Hamamatsu University School of Medicine
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin

Nyckelord

Originalspråkengelska
Artikelnummer110607
TidskriftFood and Chemical Toxicology
Volym130
Utgivningsnummersuppl 1
StatusPublished - 2019 aug
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa