RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Detaljer

Författare
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • T W Schultz
  • J Shen
  • I G Sipes
  • B Wall
  • D K Wilcox
Enheter & grupper
Externa organisationer
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • University of Minnesota system
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
Originalspråkengelska
Sidor (från-till)S49–S56
TidskriftFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volym97
Tidigt onlinedatum2015 dec 23
StatusPublished - 2016 nov
PublikationskategoriForskning
Peer review utfördJa