RIFM fragrance ingredient safety assessment, linalyl benzoate, CAS Registry Number 126-64-7

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog linalyl phenylacetate (CAS # 7143-69-3) show that this material does not have skin sensitization potential. The repeated dose toxicity endpoint was completed using linalyl cinnamate (CAS # 78-37-5) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as suitable read across analogs, which provided a MOE > 100. The local respiratory toxicity endpoint was completed using linalool (CAS # 78-70-6) and benzoic acid (CAS # 65-85-0) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework along with data from the suitable read across analog linalyl cinnamate (CAS # 78-375).

Detaljer

Författare
  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dkant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • J. F. Lalko
  • A. Lapczynski
  • D. C. Liebler
  • T. M. Penning
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
Externa organisationer
  • Columbia University
  • Skåne University Hospital
  • University of São Paulo
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Research Institute for Fragrance Materials, Inc.
  • University of Minnesota system
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmakologi och toxikologi
  • Dermatologi och venereologi

Nyckelord

Originalspråkengelska
Sidor (från-till)S180-S191
TidskriftFood and Chemical Toxicology
Volym97
StatusPublished - 2016 nov 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa