RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, l-Linalool, CAS Registry Number 126-91-0.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Detaljer

Författare
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • T W Schultz
  • J Shen
  • I G Sipes
  • B Wall
  • D K Wilcox
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
Originalspråkengelska
Sidor (från-till)S11–S24
TidskriftFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volym97
Tidigt onlinedatum2015 dec 15
StatusPublished - 2016 nov
PublikationskategoriForskning
Peer review utfördJa