Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT)

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Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). / Vossen, CY; Conard, J; Fontcuberta, J; Makris, M; Van der Meer, FJM; Pabinger, I; Palareti, G; Preston, FE; Scharrer, I; Souto, JC; Svensson, Peter; Walker, ID; Rosendaal, FR.

I: Journal of Thrombosis and Haemostasis, Vol. 3, Nr. 3, 2005, s. 459-464.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Vossen, CY, Conard, J, Fontcuberta, J, Makris, M, Van der Meer, FJM, Pabinger, I, Palareti, G, Preston, FE, Scharrer, I, Souto, JC, Svensson, P, Walker, ID & Rosendaal, FR 2005, 'Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT)', Journal of Thrombosis and Haemostasis, vol. 3, nr. 3, s. 459-464. https://doi.org/10.1111/j.1538-7836.2005.01197.x

APA

CBE

Vossen CY, Conard J, Fontcuberta J, Makris M, Van der Meer FJM, Pabinger I, Palareti G, Preston FE, Scharrer I, Souto JC, Svensson P, Walker ID, Rosendaal FR. 2005. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). Journal of Thrombosis and Haemostasis. 3(3):459-464. https://doi.org/10.1111/j.1538-7836.2005.01197.x

MLA

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Author

Vossen, CY ; Conard, J ; Fontcuberta, J ; Makris, M ; Van der Meer, FJM ; Pabinger, I ; Palareti, G ; Preston, FE ; Scharrer, I ; Souto, JC ; Svensson, Peter ; Walker, ID ; Rosendaal, FR. / Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). I: Journal of Thrombosis and Haemostasis. 2005 ; Vol. 3, Nr. 3. s. 459-464.

RIS

TY - JOUR

T1 - Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT)

AU - Vossen, CY

AU - Conard, J

AU - Fontcuberta, J

AU - Makris, M

AU - Van der Meer, FJM

AU - Pabinger, I

AU - Palareti, G

AU - Preston, FE

AU - Scharrer, I

AU - Souto, JC

AU - Svensson, Peter

AU - Walker, ID

AU - Rosendaal, FR

PY - 2005

Y1 - 2005

N2 - Background. Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies. Objectives: In the present analysis, we determined the risk of a first venous thrombotic event in carriers of a thrombophilic defect (i.e. antithrombin-, protein C- or protein S deficiency, or factor V Leiden). Patients and methods: The asymptomatic carriers had been tested prior to this study in nine European thrombosis centers because of a symptomatic, carrier in the family, and were followed prospectively for 5.7 years on average between March 1994 and January 2001. Annually, data were recorded on the occurrence of risk situations for venous thrombosis and events (e.g. venous thrombosis, death). Results: Twenty-six of the 575 asymptomatic carriers (4.5%) and seven of the 1118 controls (0.6%) experienced a first deep venous thrombosis or pulmonary embolism during follow-up. Of these events, 58% occurred spontaneously in the carriers compared with 43% in the controls. The incidence of first events was 0.8% per year (95% CI 0.5-1.2) in the carriers compared with 0.1% per year (95% CI 0.0-0.2) in the controls. The highest incidence was associated with antithrombin deficiency or combined defects, and the lowest incidence with factor V Leiden. Conclusions: The incidence of venous events in asymptomatic individuals from thrombophilic families does not exceed the risk of bleeding associated with long-term anticoagulant treatment in the literature (1-3%).

AB - Background. Reliable risk estimates for venous thrombosis in families with inherited thrombophilia are scarce but necessary for determining optimal screening and treatment policies. Objectives: In the present analysis, we determined the risk of a first venous thrombotic event in carriers of a thrombophilic defect (i.e. antithrombin-, protein C- or protein S deficiency, or factor V Leiden). Patients and methods: The asymptomatic carriers had been tested prior to this study in nine European thrombosis centers because of a symptomatic, carrier in the family, and were followed prospectively for 5.7 years on average between March 1994 and January 2001. Annually, data were recorded on the occurrence of risk situations for venous thrombosis and events (e.g. venous thrombosis, death). Results: Twenty-six of the 575 asymptomatic carriers (4.5%) and seven of the 1118 controls (0.6%) experienced a first deep venous thrombosis or pulmonary embolism during follow-up. Of these events, 58% occurred spontaneously in the carriers compared with 43% in the controls. The incidence of first events was 0.8% per year (95% CI 0.5-1.2) in the carriers compared with 0.1% per year (95% CI 0.0-0.2) in the controls. The highest incidence was associated with antithrombin deficiency or combined defects, and the lowest incidence with factor V Leiden. Conclusions: The incidence of venous events in asymptomatic individuals from thrombophilic families does not exceed the risk of bleeding associated with long-term anticoagulant treatment in the literature (1-3%).

KW - asymptomatic

KW - venous thrombosis

KW - inherited thrombophilia

U2 - 10.1111/j.1538-7836.2005.01197.x

DO - 10.1111/j.1538-7836.2005.01197.x

M3 - Article

VL - 3

SP - 459

EP - 464

JO - Journal of Thrombosis and Haemostasis

T2 - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

SN - 1538-7933

IS - 3

ER -