Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme

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Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme. / Norsker, Filippa Nyboe; Boschini, Cristina; Rechnitzer, Catherine; Holmqvist, Anna Sällfors; Tryggvadottir, Laufey; Madanat-Harjuoja, Laura Maria; Schrøder, Henrik; Scheike, Thomas H.; Hasle, Henrik; Winther, Jeanette Falck; Andersen, Klaus Kaae; ALiCCS study group.

I: Acta Oncologica, Vol. 59, Nr. 10, 2020, s. 1-11.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Norsker, FN, Boschini, C, Rechnitzer, C, Holmqvist, AS, Tryggvadottir, L, Madanat-Harjuoja, LM, Schrøder, H, Scheike, TH, Hasle, H, Winther, JF, Andersen, KK & ALiCCS study group 2020, 'Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme', Acta Oncologica, vol. 59, nr. 10, s. 1-11. https://doi.org/10.1080/0284186X.2020.1794031

APA

Norsker, F. N., Boschini, C., Rechnitzer, C., Holmqvist, A. S., Tryggvadottir, L., Madanat-Harjuoja, L. M., Schrøder, H., Scheike, T. H., Hasle, H., Winther, J. F., Andersen, K. K., & ALiCCS study group (2020). Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme. Acta Oncologica, 59(10), 1-11. https://doi.org/10.1080/0284186X.2020.1794031

CBE

Norsker FN, Boschini C, Rechnitzer C, Holmqvist AS, Tryggvadottir L, Madanat-Harjuoja LM, Schrøder H, Scheike TH, Hasle H, Winther JF, Andersen KK, ALiCCS study group. 2020. Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme. Acta Oncologica. 59(10):1-11. https://doi.org/10.1080/0284186X.2020.1794031

MLA

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Author

Norsker, Filippa Nyboe ; Boschini, Cristina ; Rechnitzer, Catherine ; Holmqvist, Anna Sällfors ; Tryggvadottir, Laufey ; Madanat-Harjuoja, Laura Maria ; Schrøder, Henrik ; Scheike, Thomas H. ; Hasle, Henrik ; Winther, Jeanette Falck ; Andersen, Klaus Kaae ; ALiCCS study group. / Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme. I: Acta Oncologica. 2020 ; Vol. 59, Nr. 10. s. 1-11.

RIS

TY - JOUR

T1 - Risk of late health effects after soft-tissue sarcomas in childhood–a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme

AU - Norsker, Filippa Nyboe

AU - Boschini, Cristina

AU - Rechnitzer, Catherine

AU - Holmqvist, Anna Sällfors

AU - Tryggvadottir, Laufey

AU - Madanat-Harjuoja, Laura Maria

AU - Schrøder, Henrik

AU - Scheike, Thomas H.

AU - Hasle, Henrik

AU - Winther, Jeanette Falck

AU - Andersen, Klaus Kaae

AU - ALiCCS study group

PY - 2020

Y1 - 2020

N2 - Background: In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed. Methods: In this population-based cohort study we identified 985 five-year soft-tissue sarcoma survivors in Nordic nationwide cancer registries and late effects in national hospital registries covering the period 1964–2012. Information on tumour site and radiotherapy was available for Danish and Finnish survivors (N = 531). Using disease-specific rates of first-time hospital contacts for somatic diseases in survivors and in 4,830 matched comparisons we calculated relative rates (RR) and rate differences (RD). Results: Survivors had a RR of 1.5 (95% CI 1.4–1.7) and an absolute RD of 23.5 (17.7–29.2) for a first hospital contact per 1,000 person-years. The highest risks in both relative and absolute terms were of endocrine disorders (RR = 2.5; RD = 7.6), and diseases of the nervous system (RR = 1.9; RD = 6.6), digestive organs (RR = 1.7; RD = 5.4) and urinary system (RR = 1.7; RD = 5.6). By tumour site, excess risk was lower after extremity tumours. Irradiated survivors had a 2.6 (1.2–5.9) times higher risk than non-irradiated. Conclusions: Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold.

AB - Background: In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effects in a large cohort of Nordic soft-tissue sarcoma survivors has not yet been assessed. Methods: In this population-based cohort study we identified 985 five-year soft-tissue sarcoma survivors in Nordic nationwide cancer registries and late effects in national hospital registries covering the period 1964–2012. Information on tumour site and radiotherapy was available for Danish and Finnish survivors (N = 531). Using disease-specific rates of first-time hospital contacts for somatic diseases in survivors and in 4,830 matched comparisons we calculated relative rates (RR) and rate differences (RD). Results: Survivors had a RR of 1.5 (95% CI 1.4–1.7) and an absolute RD of 23.5 (17.7–29.2) for a first hospital contact per 1,000 person-years. The highest risks in both relative and absolute terms were of endocrine disorders (RR = 2.5; RD = 7.6), and diseases of the nervous system (RR = 1.9; RD = 6.6), digestive organs (RR = 1.7; RD = 5.4) and urinary system (RR = 1.7; RD = 5.6). By tumour site, excess risk was lower after extremity tumours. Irradiated survivors had a 2.6 (1.2–5.9) times higher risk than non-irradiated. Conclusions: Soft-tissue sarcoma survivors have an increased risk of somatic late effects in 5 out of 10 main diagnostic groups of diseases, and the risk remains increased up to 40 years after cancer diagnosis. Risks were slightly lower for those treated for tumours in the extremities, and radiotherapy increased the risk by more than two-fold.

UR - http://www.scopus.com/inward/record.url?scp=85088296795&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2020.1794031

DO - 10.1080/0284186X.2020.1794031

M3 - Article

C2 - 32692292

AN - SCOPUS:85088296795

VL - 59

SP - 1

EP - 11

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1651-226X

IS - 10

ER -