Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

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Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. / Kazi, Julhash U.; Kabir, Nuzhat N; Rönnstrand, Lars.

I: Cellular and Molecular Life Sciences, Vol. 72, Nr. 13, 2015, s. 2535-2544.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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T1 - Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

AU - Kazi, Julhash U.

AU - Kabir, Nuzhat N

AU - Rönnstrand, Lars

PY - 2015

Y1 - 2015

N2 - SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

AB - SRC-like adaptor protein (SLAP) is an adaptor protein structurally similar to the SRC family protein kinases. Like SRC, SLAP contains an SH3 domain followed by an SH2 domain but the kinase domain has been replaced by a unique C-terminal region. SLAP is expressed in a variety of cell types. Current studies suggest that it regulates signaling of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases which are important regulator of immune and cancer cell signaling. SLAP targets receptors, or its associated components, by recruiting the ubiquitin machinery and thereby destabilizing signaling. SLAP directs receptors to ubiquitination-mediated degradation and controls receptors turnover as well as signaling. Thus, SLAP appears to be an important component in regulating signal transduction required for immune and malignant cells.

U2 - 10.1007/s00018-015-1882-6

DO - 10.1007/s00018-015-1882-6

M3 - Review article

VL - 72

SP - 2535

EP - 2544

JO - Cellular and Molecular Life Sciences

T2 - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-9071

IS - 13

ER -