Role of the DNA damage response in human papillomavirus RNA splicing and polyadenylation

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered alternative polyadenylation and splicing of HPV messenger RNA (mRNA). HPV uses the DDR machinery to replicate its DNA genome and to activate HPV late gene expression at the level of RNA processing.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Artikelnummer1735
TidskriftInternational Journal of Molecular Sciences
Volym19
Utgivningsnummer6
StatusPublished - 2018 jun 12
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Kersti Nilsson, 2019, Lund: Lund University, Faculty of Medicine. 64 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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