Ruling out risks in medical research

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Ruling out risks in medical research. / Anttila, Sten; Persson, Johannes; Rosén, Måns; Vareman, Niklas; Vitols, Sigurd; Sahlin, Nils-Eric.

I: Journal of Risk Research, Vol. 22, Nr. 6, 2019, s. 796-802.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Ruling out risks in medical research

AU - Anttila, Sten

AU - Persson, Johannes

AU - Rosén, Måns

AU - Vareman, Niklas

AU - Vitols, Sigurd

AU - Sahlin, Nils-Eric

PY - 2019

Y1 - 2019

N2 - In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However, there is a lack of standards for reporting on ruling out risks. We argue that transparency is needed, as in the case of non-inferiority trials. The Consolidated Standards of Reporting Trials and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements should be revised accordingly.

AB - In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However, there is a lack of standards for reporting on ruling out risks. We argue that transparency is needed, as in the case of non-inferiority trials. The Consolidated Standards of Reporting Trials and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements should be revised accordingly.

KW - Ruling out risks

KW - Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)

KW - value judgment

KW - transparency

KW - risk margin

KW - Consolidated Standards of Reporting Trials (CONSORT)

U2 - 10.1080/13669877.2019.1586750

DO - 10.1080/13669877.2019.1586750

M3 - Article

VL - 22

SP - 796

EP - 802

JO - Journal of Risk Research

T2 - Journal of Risk Research

JF - Journal of Risk Research

SN - 1366-9877

IS - 6

ER -