Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära

Nyckelord

Originalspråkengelska
Sidor (från-till)S290-S293
TidskriftMolecular Nutrition and Food Research
Volym55
StatusPublished - 2011
PublikationskategoriForskning
Peer review utfördJa

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