Segmental action of morphine and acupuncture-like stimulation in the dorsal horn of the rat as visualized by the 14C-2-deoxyglucose method
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It is not clear where analgesic measures such as morphine and acupuncture have their sites of action. Since analgesia from acupuncturelike stimulation is reversed by naloxone (Sjolund and Eriksson, Brain Res. 173:295, 1979) it is probably mediated via endorphins. The two analgesic procedures mentioned may thus use similar inhibitory mechanisms. We now present data from autoradiographic measurements of regional 'nervous' activity (Sokoloff et al., J. Neurochem., 28:897, 1977) in the rat spinal cord, indicating that the inhibition is present already in the outer dorsal horn laminae.