Selected biomarkers correlate with the origin and severity of sepsis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.

Detaljer

Författare
  • Michal Holub
  • Olga Dupová
  • Michaela Ruková
  • Alzbeta Stráníková
  • Eva Bartáková
  • Jan Máca
  • Jirí Bene
  • Heiko Herwald
  • Ondrej Beran
Enheter & grupper
Externa organisationer
  • Charles University in Prague
  • The Military University Hospital Prague
  • Bulovka Hospital
  • University Hospital Ostrava
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Originalspråkengelska
Artikelnummer7028267
TidskriftMediators of Inflammation
Volym2018
StatusPublished - 2018 mar 27
PublikationskategoriForskning
Peer review utfördJa