Selected contribution: role of spleen emptying in prolonging apneas in humans

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Selected contribution: role of spleen emptying in prolonging apneas in humans. / Schagatay, Erica; Andersson, Johan P.; Hallén, Magnus; Pålsson, Birger.

I: Journal of Applied Physiology, Vol. 90, Nr. 4, 2001, s. 1623-9; discussion 1606-1623-9; discussion 1606.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Schagatay, E, Andersson, JP, Hallén, M & Pålsson, B 2001, 'Selected contribution: role of spleen emptying in prolonging apneas in humans', Journal of Applied Physiology, vol. 90, nr. 4, s. 1623-9; discussion 1606-1623-9; discussion 1606.

APA

Schagatay, E., Andersson, J. P., Hallén, M., & Pålsson, B. (2001). Selected contribution: role of spleen emptying in prolonging apneas in humans. Journal of Applied Physiology, 90(4), 1623-9; discussion 1606-1623-9; discussion 1606.

CBE

Schagatay E, Andersson JP, Hallén M, Pålsson B. 2001. Selected contribution: role of spleen emptying in prolonging apneas in humans. Journal of Applied Physiology. 90(4):1623-9; discussion 1606-1623-9; discussion 1606.

MLA

Schagatay, Erica et al. "Selected contribution: role of spleen emptying in prolonging apneas in humans". Journal of Applied Physiology. 2001, 90(4). 1623-9; discussion 1606-1623-9; discussion 1606.

Vancouver

Schagatay E, Andersson JP, Hallén M, Pålsson B. Selected contribution: role of spleen emptying in prolonging apneas in humans. Journal of Applied Physiology. 2001;90(4):1623-9; discussion 1606-1623-9; discussion 1606.

Author

Schagatay, Erica ; Andersson, Johan P. ; Hallén, Magnus ; Pålsson, Birger. / Selected contribution: role of spleen emptying in prolonging apneas in humans. I: Journal of Applied Physiology. 2001 ; Vol. 90, Nr. 4. s. 1623-9; discussion 1606-1623-9; discussion 1606.

RIS

TY - JOUR

T1 - Selected contribution: role of spleen emptying in prolonging apneas in humans

AU - Schagatay, Erica

AU - Andersson, Johan P.

AU - Hallén, Magnus

AU - Pålsson, Birger

PY - 2001

Y1 - 2001

N2 - This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas.

AB - This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas.

KW - Adult

KW - Apnea

KW - Blood Pressure/physiology

KW - Blood Proteins/metabolism

KW - Carbon Dioxide/blood

KW - Face

KW - Female

KW - Heart Rate/physiology

KW - Hematocrit

KW - Hemoglobins/metabolism

KW - Humans

KW - Immersion

KW - Lung Volume Measurements

KW - Male

KW - Regional Blood Flow/physiology

KW - Spleen/ physiology

KW - Splenectomy

M3 - Article

VL - 90

SP - 1623-9; discussion 1606-1623-9; discussion 1606

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 1522-1601

IS - 4

ER -