Sensing DNA–DNA as Nanosensor: A Perspective Towards Nanobiotechnology

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employing single molecule fluorescence methods, we propose to make use of the physics of DNA denaturation nanoregions to find out about the solvent conditions such as ionic strength, presence of binding proteins, etc. Bymeasuring dynamical quantities in particular, rather sensitive nanoprobes may be constructed with contemporary instruments.

Detaljer

Författare
Externa organisationer
  • Nordic Institute for Theoretical Atomic Physics (NORDITA)
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysikalisk kemi
Originalspråkengelska
Sidor (från-till)389-395
TidskriftJournal of Computational and Theoretical Nanoscience
Volym2
Utgivningsnummer3
StatusPublished - 2005 sep 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa