Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography

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Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography. / Arboleda, Carolina; Wang, Zhentian; Koehler, Thomas; Martens, Gerhard; Van Stevendaal, Udo; Bartels, Matthias; Villanueva-Perez, Pablo; Roessl, Ewald; Stampanoni, Marco.

I: Optics Express, Vol. 25, Nr. 6, 20.03.2017, s. 6349-6364.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Arboleda, C, Wang, Z, Koehler, T, Martens, G, Van Stevendaal, U, Bartels, M, Villanueva-Perez, P, Roessl, E & Stampanoni, M 2017, 'Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography', Optics Express, vol. 25, nr. 6, s. 6349-6364. https://doi.org/10.1364/OE.25.006349

APA

Arboleda, C., Wang, Z., Koehler, T., Martens, G., Van Stevendaal, U., Bartels, M., ... Stampanoni, M. (2017). Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography. Optics Express, 25(6), 6349-6364. https://doi.org/10.1364/OE.25.006349

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MLA

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Author

Arboleda, Carolina ; Wang, Zhentian ; Koehler, Thomas ; Martens, Gerhard ; Van Stevendaal, Udo ; Bartels, Matthias ; Villanueva-Perez, Pablo ; Roessl, Ewald ; Stampanoni, Marco. / Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography. I: Optics Express. 2017 ; Vol. 25, Nr. 6. s. 6349-6364.

RIS

TY - JOUR

T1 - Sensitivity-based optimization for the design of a grating interferometer for clinical X-ray phase contrast mammography

AU - Arboleda, Carolina

AU - Wang, Zhentian

AU - Koehler, Thomas

AU - Martens, Gerhard

AU - Van Stevendaal, Udo

AU - Bartels, Matthias

AU - Villanueva-Perez, Pablo

AU - Roessl, Ewald

AU - Stampanoni, Marco

PY - 2017/3/20

Y1 - 2017/3/20

N2 - An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.

AB - An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is remarkably challenging. In this work, we present a wave propagation based optimization that uses the phase and dark-field sensitivities as figures of merit. This method was used to calculate the optimal interferometer designs for a commercial mammography setup. Its accuracy was validated by measuring the visibility of polycarbonate samples of different thicknesses on a Talbot-Lau interferometer installed on this device and considering some of the most common grating imperfections to be able to reproduce the experimental values. The optimization method outcomes indicate that small grating pitches are required to boost sensitivity in such a constrained setup and that there is a different optimal scenario for each signal type.

U2 - 10.1364/OE.25.006349

DO - 10.1364/OE.25.006349

M3 - Article

VL - 25

SP - 6349

EP - 6364

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 6

ER -