Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment. In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Cell- och molekylärbiologi
Originalspråkengelska
Sidor (från-till)283-285
Antal sidor3
TidskriftCell Stem Cell
Volym22
Utgivningsnummer3
StatusPublished - 2018 mar 1
PublikationskategoriForskning
Peer review utfördJa