Separation of pathogenic bacteria by chain length

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Nanyang Technological University
  • Karolinska Institute
  • Karolinska University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)223–231
TidskriftAnalytica Chimica Acta
Volym1000
StatusPublished - 2018
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Bao Dang Ho, 2018 okt 18, Department of Physics, Lund University. 199 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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