Sequence evolution in a chromosomal region of Arabidopsis thaliana

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Standard

Sequence evolution in a chromosomal region of Arabidopsis thaliana. / Hagenblad, Jenny.

Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden, 2002. 76 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

Harvard

Hagenblad, J 2002, 'Sequence evolution in a chromosomal region of Arabidopsis thaliana', Doktor, Biologiska institutionen.

APA

Hagenblad, J. (2002). Sequence evolution in a chromosomal region of Arabidopsis thaliana. Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden,.

CBE

Hagenblad J. 2002. Sequence evolution in a chromosomal region of Arabidopsis thaliana. Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden,. 76 s.

MLA

Hagenblad, Jenny Sequence evolution in a chromosomal region of Arabidopsis thaliana Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden,. 2002.

Vancouver

Hagenblad J. Sequence evolution in a chromosomal region of Arabidopsis thaliana. Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden, 2002. 76 s.

Author

Hagenblad, Jenny. / Sequence evolution in a chromosomal region of Arabidopsis thaliana. Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden, 2002. 76 s.

RIS

TY - THES

T1 - Sequence evolution in a chromosomal region of Arabidopsis thaliana

AU - Hagenblad, Jenny

N1 - Defence details Date: 2002-09-21 Time: 10:00 Place: Genetics building, Sölveg. 29, Lund External reviewer(s) Name: Savolainen, Outi Title: Prof. Affiliation: [unknown] --- Article: Nordborg M, Borevitz JO, et al. The extent of Linkage Disequilibrium in Arabidopsis thaliana. Nature Genetics 30:190-193, 2002Hagenblad J, Nordborg M. Sequence variation and haplotype structure surrounding the flowering time locus FRI in Arabidopsis thaliana. Genetics 161:289-298, 2002Hagenblad J, Nordborg M. Molecular genetics of the allotetraploid Arabidopsis suecica and its parental species. Manuscript, 2002Hagenblad J, Nordborg M. Haplotype evolution around the locus FRI in Arabidopsis thaliana. Manuscript, 2002 The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Genetics (Closed 2011) (011005100)

PY - 2002

Y1 - 2002

N2 - Recently there has been a lot of interest in the use of liknage disequilibrium (LD) in genome wide scans for new genes, so called association mapping. Of crucial importance to a genome wide scan for associations between genetic markers and the trait of interest is the extent of LD, as it determines both how closely a trait can be mapped and also how many markers is needed to map it. Most outbreeding organisms such as Drosophila melanogaster and maize have too little LD to be useful for association mapping. As LD breaks down much more slowly in predominantly self-fertilising organisms, they can, however, be expected to have much higher levels of LD. It is shown here that the self-fertilising model plant Arabidopsis thaliana holds a lot of promise of being a suitable organism for LD-mapping. Around the flowering time locus FRI, the levels of LD were suitable for LD-mapping. Some of the problems with LD-mapping is also addressed as allelic heterogeneity had a major impact on LD in the region studied. Also some of the basic population genetic parameters for the region are discussed as is geographical subdivision among Arabidopsis thaliana and possible history of the different FRI alleles.

AB - Recently there has been a lot of interest in the use of liknage disequilibrium (LD) in genome wide scans for new genes, so called association mapping. Of crucial importance to a genome wide scan for associations between genetic markers and the trait of interest is the extent of LD, as it determines both how closely a trait can be mapped and also how many markers is needed to map it. Most outbreeding organisms such as Drosophila melanogaster and maize have too little LD to be useful for association mapping. As LD breaks down much more slowly in predominantly self-fertilising organisms, they can, however, be expected to have much higher levels of LD. It is shown here that the self-fertilising model plant Arabidopsis thaliana holds a lot of promise of being a suitable organism for LD-mapping. Around the flowering time locus FRI, the levels of LD were suitable for LD-mapping. Some of the problems with LD-mapping is also addressed as allelic heterogeneity had a major impact on LD in the region studied. Also some of the basic population genetic parameters for the region are discussed as is geographical subdivision among Arabidopsis thaliana and possible history of the different FRI alleles.

KW - Växtgenetik

KW - Plant genetics

KW - flowering time

KW - mapping

KW - polymorphism

KW - Linkage disequilibrium

KW - Arabidopsis thaliana

M3 - Doctoral Thesis (compilation)

SN - 91-628-5356-2

PB - Jenny Hagenblad, Genetics, Sölvegatan 29, 22362 Lund, Sweden,

ER -