SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Detaljer

Författare
  • G Appendino
  • S Prosperini
  • Carola Valdivia
  • M Ballero
  • G Colombano
  • R A Billington
  • A A Genazzani
  • Olov Sterner
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
Sidor (från-till)1213-1217
TidskriftJournal of Natural Products
Volym68
Utgivningsnummer8
StatusPublished - 2005
PublikationskategoriForskning
Peer review utfördJa