Serum IgE reactivity to Malassezia furfur extract and recombinant M-furfur allergens in patients with atopic dermatitis

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IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1. rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. fin fur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur-associated I-E allergies in patients with AD.


  • A. Zargari
  • H. Eshaghi
  • Ove Bäck
  • S. Johansson
  • A. Scheynius
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi
Sidor (från-till)418-422
TidskriftActa Dermato-Venereologica
Utgåva nummer6
StatusPublished - 2001
Peer review utfördJa