Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Data from our study provided evidence for a possible role of serum triglycerides in cancer development.

Detaljer

Författare
  • Wegene Borena
  • Tanja Stocks
  • Hakan Jonsson
  • Susanne Strohmaier
  • Gabriele Nagel
  • Tone Bjorge
  • Jonas Manjer
  • Goeran Hallmans
  • Randi Selmer
  • Martin Almquist
  • Christel Haggstrom
  • Anders Engeland
  • Steinar Tretli
  • Hans Concin
  • Alexander Strasak
  • Paer Stattin
  • Hanno Ulmer
Enheter & grupper
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)291-299
TidskriftCancer Causes and Control
Volym22
Utgåva nummer2
StatusPublished - 2011
PublikationskategoriForskning
Peer review utfördJa