Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.

Detaljer

Författare
  • B Zierhut
  • T Daneva
  • W Gartner
  • B Brunnmaier
  • I Mineva
  • Tord Berggård
  • L Wagner
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Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biologiska vetenskaper
Originalspråkengelska
Sidor (från-till)1193-1199
TidskriftBiochemical and Biophysical Research Communications
Volym329
Utgivningsnummer4
StatusPublished - 2005
PublikationskategoriForskning
Peer review utfördJa