Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
  • Infektionsmedicin

Nyckelord

Originalspråkengelska
Sidor (från-till)1415-1424
TidskriftJournal of Experimental Medicine
Volym192
Utgåva nummer10
StatusPublished - 2000
PublikationskategoriForskning
Peer review utfördJa